July 7, 2023

Unveiling the Crucial Role of Vitamin D in Menopause and Adrenal Health

Ozark Holistic Center

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STUDY LINK: Vitamin D and adrenal gland: Myth or reality? A systematic review


Menopause is a significant phase in a woman’s life, marked by hormonal shifts that affect various aspects of her well-being. Among the organs involved in this transition, the adrenal glands play a vital role in hormone production. In particular, vitamin D has emerged as a key player in maintaining adrenal health during menopause. In this blog post, we explore the insights shared by Dr. Orie Quinn, DC, and a corresponding study to understand the profound impact of vitamin D on menopause and adrenal gland function.

The Shift in Hormone Production during Menopause:

Dr. Orie Quinn, DC, emphasizes that during menopause, there is a transfer of hormone production from the ovaries to the adrenal glands. The health and functionality of the adrenal glands become crucial factors that influence a woman’s experience and symptoms during this transitional period. While several deficiencies can contribute to adrenal dysfunction, vitamin D deficiency is commonly observed.

Vitamin D’s Role in Adrenal Health:

Vitamin D is renowned for its role in calcium metabolism and skeletal health. However, recent research has illuminated its multifaceted functions, including immune modulation, inflammation control, and cortisol regulation. Cortisol, often referred to as the stress hormone, plays a pivotal role in maintaining hormone balance within the adrenal glands. Vitamin D’s ability to regulate cortisol levels suggests its potential to support hormonal equilibrium during menopause.

Exploring the Study:

In line with Dr. Orie Quinn’s observations, a study published in the National Library of Medicine examines the influence of vitamin D on adrenal gland diseases and their associated pathologies. The study encompasses conditions such as Cushing’s disease, adrenal cortex tumors, hyperaldosteronism, and Addison’s disease.

Cushing’s Disease and Vitamin D: The study reveals that individuals with Cushing’s disease tend to have lower levels of 25-hydroxyvitamin D (25OHD) compared to control subjects. Furthermore, these reduced vitamin D levels appear to correlate negatively with urinary cortisol levels.

Adrenal Cortex Tumors and Vitamin D: Vitamin D deficiency and under-expression of vitamin D receptors (VDR) seem to be linked to adrenal cortex tumors. This finding suggests a potential relationship between vitamin D status and the development of such tumors.

Hyperaldosteronism and Hypertension: The research indicates that vitamin D deficiency is associated with activation of the Renin-Angiotensin-Aldosterone System (RAAS), leading to hyperaldosteronism and hypertension. There are indications that vitamin D administration may help modulate hyperaldosteronism and its associated hypertension.

Addison’s Disease and Autoimmunity: Vitamin D’s immunomodulatory properties make it a potentially protective factor in autoimmune diseases like Addison’s disease. However, further investigation is necessary to elucidate the mechanisms involved and the therapeutic implications.

Implications and Future Perspectives:

Although the studies reviewed provide promising insights, it is important to acknowledge the current limitations and lack of conclusive evidence. Therefore, diagnostic and therapeutic conclusions for adrenal diseases cannot be formulated solely based on existing research.

While the clinical efficacy of vitamin D supplementation for adrenal diseases remains uncertain, the findings open up avenues for potential therapeutic and preventive applications. Future studies should focus on determining the optimal dosage, duration, and impact of vitamin D supplementation on the development, progression, and prognosis of adrenal pathologies.


The link between vitamin D and adrenal health during menopause is more than just speculation. Dr. Orie Quinn’s observations and the corresponding study highlight the intricate interactions between adrenal hormones and vitamin D, with potential implications for prevention and overall well-being. However, further research is needed to solidify our understanding and provide clear guidelines for the clinical use of vitamin D in adrenal diseases. As we embark on this journey of discovery, it is evident that the connection between vitamin D and adrenal gland health holds great promise for women’s health during menopause and beyond.

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